Keywords
How to Cite
Abstract
Hozirgi zamon biotexnologiyalarining eng ilg‘or yo‘nalishlaridan biri CRISPR-Cas9 texnologiyasidir. Bu usul genetik tahrirlash vositasi sifatida turli irsiy kasalliklarni davolash va oldini olishda samarali vosita sifatida qaralmoqda. Ushbu maqolada CRISPR-Cas9 texnologiyasining ishlash mexanizmi, genetik kasalliklarni davolashdagi amaliy qo‘llanilishi va kelajak istiqbollari batafsil tahlil qilinadi. Shuningdek, CRISPR bilan bog‘liq xavfsizlik, axloqiy va huquqiy muammolar ham muhokama etiladi.
References
1. Doudna, J. A., & Charpentier, E. (2020). The new frontier of genome engineering with CRISPR-Cas9. Science, 368(6488), 1077-1083. https://doi.org/10.1126/science.abb8739
2. Barrangou, R., & Horvath, P. (2019). CRISPR-Cas systems: RNA-mediated adaptive immunity in bacteria and archaea. Nature Reviews Microbiology, 17(2), 109-123. https://doi.org/10.1038/s41579-018-0115-7
3. Ledford, H. (2021). CRISPR gene therapy: New developments and future perspectives. Nature, 593(7857), 30-32. https://doi.org/10.1038/d41586-021-01222-7
4. Cox, D. B. T., Platt, R. J., & Zhang, F. (2020). Therapeutic genome editing: Prospects and challenges. Nature Medicine, 26(7), 980-988. https://doi.org/10.1038/s41591-020-0937-z
5. National Academies of Sciences, Engineering, and Medicine (NASEM). (2022). Human Genome Editing: Science, Ethics, and Governance. National Academies Press. https://doi.org/10.17226/24623
