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Abstract
So‘nggi yillarda ichak mikrobiotasi metabolik salomatlikni belgilovchi muhim biologik tizim sifatida keng o‘rganilmoqda. Inson organizmida yashovchi trillionlab mikroorganizmlar nafaqat ovqat hazm qilish jarayonlarida, balki energiya almashinuvi, immun javob, yallig‘lanish reaksiyalari va glyukoza gomeostazini boshqarishda ham faol ishtirok etadi. Ushbu maqolada ichak mikrobiotasi va insulinrezistentlik o‘rtasidagi bog‘liqlikning zamonaviy patogenetik mexanizmlari tahlil qilindi. Adabiyotlar sharhi natijalari disbioz holati ichak to‘sig‘i funksiyasining buzilishi, metabolik endotoksemiya, surunkali past darajadagi yallig‘lanish va insulin signalizatsiyasining izdan chiqishi bilan chambarchas bog‘liqligini ko‘rsatdi. Shuningdek, qisqa zanjirli yog‘ kislotalari ishlab chiqaruvchi bakteriyalar sonining kamayishi insulin sezuvchanligining pasayishiga olib kelishi aniqlangan. Epidemiologik tadqiqotlar ichak mikrobiotasi tarkibidagi o‘zgarishlar semizlik, prediabet va 2-tip qandli diabet rivojlanish xavfini oshirishini tasdiqlaydi. Zamonaviy ilmiy dalillar probiotiklar, prebiotiklar va mikrobiota yo‘naltirilgan dietoterapiya insulinrezistentlik profilaktikasi hamda davolashning istiqbolli yo‘nalishlaridan biri ekanligini ko‘rsatmoqda
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