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Abstract
0–3 yoshdagi bolalarda erta antibiotikoterapiya ichak mikrobiomasida vaqtinchalik disbiozga sabab bo‘lib, o‘tkir ta’sir davrida xilma-xillikni pasaytiradi, ammo 1–2 oy ichida tiklanishni ta’minlaydi. Uzoq muddatli ta’sirlar patogenlar (masalan, Enterobacteriales)ni selektiv ravishda bostirish, umumiy xilma-xillikka minimal ta’sir va immun javobning o‘zgarishini o‘z ichiga oladi, bu allergiya, metabolik buzilishlar va vaktsina immunogenligi o‘zgarishlari xavfini oshirishi mumkin. Ehtiyotkorlik bilan qo‘llash mikrobial muvozanatni saqlash va salbiy salomatlik yo‘nalishlarini yumshatish uchun zarur.
References
1.Kwon, Y., Cho, Y.-S., Lee, Y.-M., Kim, S.-j., Bae, J., & Jeong, S.-J. (2022). Changes to Gut Microbiota Following Systemic Antibiotic Administration in Infants. Antibiotics, 11(4), 470. https://doi.org/10.3390/antibiotics11040470.
2.Akagawa, Y., Kimata, T., Akagawa, S., Yamaguchi, T., Kato, S., Yamanouchi, S., Hashiyada, M., Akane, A., Kino, M., Tsuji, S., & Kaneko, K. (2020). Impact of Long-Term Low Dose Antibiotic Prophylaxis on Gut Microbiota in Children. The Journal of urology, 204(6), 1320–1325. https://doi.org/10.1097/JU.0000000000001227
3.Benitez, A. J., Tanes, C., Friedman, E. S., Zackular, J. P., Ford, E., Gerber, J. S., DeRusso, P.A., Kelly, A., Li, H., Elovitz, M.A., Wu, G.D., Zemel, B., & Bittinger, K. (2025). Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants. Microbiome, 13(1), 21. https://doi.org/10.1186/s40168-024-01999-3
4.Jordan, A., Carding, S. R., & Hall, L. J. (2022). The early-life gut microbiome and vaccine efficacy. The Lancet Microbe. https://doi.org/10.1016/S2666-5247(22)00185-9
5.Borrego-Ruiz, A., & Borrego, J. J. (2025). Early-life gut microbiome development and its potential long-term impact on health outcomes. Microbiome research reports, 4(2), 20. https://doi.org/10.20517/mrr.2024.78
6.Thursby, E.; Juge, N. Introduction to the human gut microbiota.Biochem. J. 2017, 474, 1823–1836.
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